The duration of action of Malegra FXT Plus, particularly the Sildenafil component, is similar to other PDE5 inhibitors used to treat ED, such as Viagra (Sildenafil), Cialis (Tadalafil), and Levitra (Vardenafil). The effects of Sildenafil typically last for about 4 to 6 hours after ingestion.

It is important to note that the duration of action of Malegra FXT Plus, or any medication, can vary from person to person. Several factors can influence how long the medication remains active in an individual's system, including their metabolism, age, overall health, and the presence of other medications or medical conditions.

Fluoxetine, the other active ingredient in Malegra FXT Plus, is an SSRI used to treat depression and may not directly affect the duration of action of Sildenafil. However, as with any medication, Fluoxetine may have its own onset and duration of action for the treatment of depression and anxiety disorders.

If you have any concerns about the duration of action or any other aspects of Malegra FXT Plus, it is crucial to discuss them with your healthcare provider. They can provide personalized information based on your medical history and guide you on the most appropriate use of the medication for your specific needs.