Yes, certain medical conditions and medications can interact negatively with taking Vilitra 60 mg pills. It's crucial to discuss your medical history and current medications with your healthcare provider before starting Vilitra 60 mg or any other dosage of Vilitra. Some potential interactions to be aware of include:

Nitrates: Vardenafil, the active ingredient in Vilitra, can potentiate the hypotensive effects of nitrates, leading to a significant decrease in blood pressure. Therefore, taking Vilitra with nitrates (commonly used to treat angina and chest pain) is contraindicated and can result in a life-threatening drop in blood pressure.

Alpha-blockers: Concomitant use of alpha-blockers with Vilitra can also lead to significant hypotension. Caution is advised when using these medications together, and adjustments in dosage may be necessary.

Other medications: Certain medications used to treat HIV/AIDS, fungal infections, or bacterial infections may interact with Vardenafil, either increasing or decreasing its levels in the body. It's important to discuss all medications you are taking with your healthcare provider to ensure there are no potential interactions.

Cardiovascular conditions: Individuals with pre-existing cardiovascular conditions, such as heart disease, stroke, or arrhythmias, may be at increased risk of complications when taking Vilitra due to its effects on blood pressure and heart rate.

Priapism risk: Conditions predisposing to priapism (a prolonged and painful erection), such as sickle cell anemia, multiple myeloma, or leukemia, may be exacerbated by Vilitra. Patients with a history of priapism should use Vilitra with caution.

Vision problems: Vardenafil has been associated with rare cases of non-arteritic anterior ischemic optic neuropathy (NAION), a condition that can lead to sudden vision loss. Individuals with a history of NAION or other vision problems should use Vilitra cautiously and discuss any concerns with their healthcare provider.