Not sure about the occurrence of five, though it was cute to see Roddy McDowall and Anne Francis from "Short Fuse" reunite in an episode of "Matlock" years later.
Yesterday I watched the TV movie "Fireball Forward" (1972), with at least eight names related to "Columbo": Ben Gazzara (director in the series), Ricardo Montalban, Anne Francis, Dana Elcar, L.Q. Jones, Eddie Albert, Kenneth Tobey and Don Eitner.