I agree with headache. I think Joe Pesce would probably do an excellent job as Columbo. His role in My Cousin Vinny already has some elements in common with Columbo, and his physical appearance is also similar. He's also a superb actor.
Even though I wouldn't really want to see someone else play the part, one person who occured to me is Kevin Pollack. I thought of him because he does a very good Peter falk imitation (not that an actual IMITATION would be called for). But THEN it occured to me that he has a knack for playing "quirky" characters in a way that isn't OVERDONE, just like Peter Falk himself.